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Synthesis of β‐amyloid precursor peptide and presenilin segments
Author(s) -
Baláspiri Lajos,
Langel Ülo
Publication year - 2001
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.305
Subject(s) - presenilin , peptide , peptide synthesis , amyloid precursor protein , solid phase synthesis , chemistry , amyloid (mycology) , biochemistry , combinatorial chemistry , computational biology , alzheimer's disease , biology , disease , medicine , inorganic chemistry
It seems likely that the β‐amyloid precursor protein (APP) and the presenilins (PS‐1/2) play important roles in the development of Alzheimer's disease (AD). Attempts to mimic the biochemical actions of these proteins are often made by the application of fragments of these proteins. However, the synthesis of these segments by conventional methods of peptide synthesis is problematic. We have synthesized several C ‐terminal fragments of APP and PS‐1/2 by solid‐phase synthesis through combination of automatic and manual methods of synthesis. This permits solution of the ‘difficult sequences’ in the solid‐phase synthesis of these peptides. Some details of the syntheses of nine segments are presented in this paper. Copyright © 2001 European Peptide Society and John Wiley & Sons, Ltd.