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Cu(OBt) 2 and Cu(OAt) 2 , copper(II)‐based racemization suppressors ready for use in fully automated solid‐phase peptide synthesis
Author(s) -
Van Den Nest Wim,
Yuval Shov,
Albericio Fernando
Publication year - 2001
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.299
Subject(s) - racemization , copper , peptide synthesis , chemistry , peptide , combinatorial chemistry , solid phase synthesis , reagent , phase (matter) , organic chemistry , biochemistry
The complexes Cu(OBt) 2 and Cu(OAt) 2 , which are derived from copper(II) and HOBt and HOAt, respectively, are shown to be more effective in suppressing racemization during solid‐phase peptide synthesis (SPPS) than are those compounds currently being used for this purpose. These compounds can readily be used in conjunction with the commonly applied coupling reagents in fully automated systems for solid‐phase peptide chemistry. Copyright © 2001 European Peptide Society and John Wiley & Sons, Ltd.