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Antifungal effect and action mechanism of antimicrobial peptide polybia‐CP
Author(s) -
Wang Kairong,
Jia Fengjing,
Dang Wen,
Zhao Yanyan,
Zhu Ranran,
Sun Mengyang,
Qiu Shuai,
An Xiaoping,
Ma Zelin,
Zhu Yuanyuan,
Yan Jiexi,
Kong Ziqing,
Yan Wenjin,
Wang Rui
Publication year - 2016
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.2835
Subject(s) - antimicrobial , antifungal , microbiology and biotechnology , fungicide , antimicrobial peptides , biology , mode of action , pharmacology , chemistry , toxicology , botany
The incidence of life‐threatening invasive fungal infections increased significantly in recent years. However, the antifungal therapeutic options are very limited. Antimicrobial peptides are a class of potential lead chemical for the development of novel antifungal agents. Antimicrobial peptide polybia‐CP was purified from the venom of the social wasp Polybia paulista . In this study, we synthesized polybia‐CP and determined its antifungal effects against a series of Candidian species. Our results showed that polybia‐CP has potent antifungal activity and fungicidal activity against the tested fungal cells with a proposed membrane‐active action mode. In addition, polybia‐CP could induce the increase of cellular reactive oxygen species production, which would attribute to its antifungal activity. In conclusion, the present study suggests that polybia‐CP has potential as an antifungal agent or may offer a new strategy for antifungal therapeutic option. Copyright © 2015 European Peptide Society and John Wiley & Sons, Ltd.