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Development of stapled helical peptides to perturb the Cdt1–Mcm6 interaction
Author(s) -
Lee Jonghan Peter,
Liu Changdong,
Li Tianlu,
Zhu Guang,
Li Xuechen
Publication year - 2015
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.2779
Subject(s) - chemistry , computational biology , biology
Six all‐hydrocarbon‐stapled Cdt1 MBD‐derived peptides have been designed and synthesized to perturb the Cdt1–Mcm6 interaction, which is involved in DNA replication. Inconsistency between the helicity of the obtained peptidomimetics and their binding affinity has been observed. The helicity of 13‐amino acid stapled peptides increased, while their binding to Mcm6 was decreased. On the other hand, the 30‐amino acid stapled peptides exhibited decreased helicity but increased binding affinity. Copyright © 2015 European Peptide Society and John Wiley & Sons, Ltd.