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Turning peptides in comb silicone polymers
Author(s) -
Jebors Said,
Pinese Coline,
Nottelet Benjamin,
Parra Karine,
Amblard Muriel,
Mehdi Ahmad,
Martinez Jean,
Subra Gilles
Publication year - 2015
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.2757
Subject(s) - cationic polymerization , silicone , polymerization , polymer , peptide , polymer chemistry , side chain , chemistry , yield (engineering) , amino acid , coating , combinatorial chemistry , organic chemistry , materials science , biochemistry , metallurgy
We have recently reported on a new class of silicone–peptide‵ biopolymers obtained by polymerization of di‐functionalized chlorodimethylsilyl hybrid peptides. Herein, we describe a related strategy based on dichloromethylsilane‐derived peptides, which yield novel polymers with a polysiloxane backbone, comparable with a silicone‐bearing pendent peptide chains. Interestingly, polymerization is chemoselective toward amino acids side‐chains and proceeds in a single step in very mild conditions (neutral pH, water, and room temperature). As potential application, a cationic sequence was polymerized and used for antibacterial coating. Copyright © 2015 European Peptide Society and John Wiley & Sons, Ltd.