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Solid‐phase synthesis of C‐terminal azapeptides
Author(s) -
Doan NgocDuc,
Zhang Jinqiang,
Traoré Mariam,
Kamdem Winnie,
Lubell William D.
Publication year - 2015
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.2711
Subject(s) - regioselectivity , solid phase synthesis , residue (chemistry) , peptide , alkylation , peptide synthesis , combinatorial chemistry , chemistry , stereochemistry , terminal (telecommunication) , biochemistry , catalysis , computer science , telecommunications
The solid‐phase synthesis of azapeptides possessing a C‐terminal aza‐residue has been accomplished by a protocol featuring regioselective alkylation of benzhydrylidene‐aza‐glycinamide and illustrated by the syntheses of [aza‐Lys 6 ] growth‐hormone‐releasing peptide‐6 analogs. Copyright © 2015 European Peptide Society and John Wiley & Sons, Ltd.