Premium
Matrix‐assisted peptide synthesis on nanoparticles
Author(s) -
Khandadash Raz,
Machtey Victoria,
Weiss Aryeh,
Byk Gerardo
Publication year - 2014
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.2664
Subject(s) - peptide , nanoparticle , matrix (chemical analysis) , peptide synthesis , combinatorial chemistry , chemistry , nanotechnology , magnetic nanoparticles , materials science , chromatography , biochemistry
We report a new method for multistep peptide synthesis on polymeric nanoparticles of differing sizes. Polymeric nanoparticles were functionalized via their temporary embedment into a magnetic inorganic matrix that allows multistep peptide synthesis. The matrix is removed at the end of the process for obtaining nanoparticles functionalized with peptides. The matrix‐assisted synthesis on nanoparticles was proved by generating various biologically relevant peptides. Copyright © 2014 European Peptide Society and John Wiley & Sons, Ltd.