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Introduction of histidine units using benzotriazolide activation
Author(s) -
Bajaj Kiran,
Panda Siva S.,
Ibrahim Mohamed A.,
ElFeky Said A.,
Katritzky Alan R.
Publication year - 2013
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.2483
Subject(s) - histidine , chemistry , biochemistry , amino acid
N α ‐Boc‐ N im ‐(4‐toluenesulfonyl‐ l ‐histidylbenzotriazole) enables convenient acylation of N ‐, O ‐, S ‐, and C ‐nucleophiles with no detectable racemization. We report efficient syntheses of novel histidine‐containing di‐, tri‐, and tetra‐peptides and models for the preparation of potentially biologically active histidine N ‐, O ‐, S ‐, and C ‐conjugates. Copyright © 2013 European Peptide Society and John Wiley & Sons, Ltd.
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