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Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery
Author(s) -
Accardo Antonella,
Mangiapia Gaetano,
Paduano Luigi,
Morelli Giancarlo,
Tesauro Diego
Publication year - 2013
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.2481
Subject(s) - liposome , amphiphile , chemistry , bilayer , drug delivery , doxorubicin , hydrodynamic radius , somatostatin receptor , dynamic light scattering , somatostatin receptor 2 , cisplatin , biophysics , micelle , nuclear chemistry , materials science , membrane , nanotechnology , receptor , organic chemistry , biochemistry , nanoparticle , copolymer , chemotherapy , aqueous solution , polymer , medicine , surgery , biology
The synthesis, formulation and a complete physico‐chemical characterization, by dynamic light scattering and small angle neutron scattering techniques, of new liposomal aggregates obtained by co‐assembling an amphiphilic molecule containing a platinum complex, Peg 1500 ‐Lys(Pt‐aminoEtGly)‐Lys(C18) 2 , (abbreviated as (C18) 2 ‐PKAG‐Pt), with a second amphiphilic monomer, (C 18 H 37 ) 2 NCO(CH 2 ) 2 CO(AdOO) 5 ‐Oct ((C18) 2 L 5 ‐Oct), containing the octreotide bioactive peptide, is reported. Liposomes of (C18) 2 ‐PKAG‐Pt present a radius of 48 nm, whereas the mixed aggregates (C18) 2 ‐PKAG‐Pt/(C18) 2 L 5 ‐Oct at 90/10 M ratio give larger liposomes with a radius of 84 nm. In both cases, the bilayer thickness is ~5.3 nm. Encapsulation of doxorubicin in mixed liposomes is also obtained by using the pH gradient method. The obtained liposomes could represent a new target selective cargo system for delivery of cisplatin based drugs and/or doxorubicin on cells overexpressing the sstr2 and sstr5 somatostatin receptors. Copyright © 2013 European Peptide Society and John Wiley & Sons, Ltd.