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Solid phase synthesis of peptide hydroxamic acids on poly(ethylene glycol)‐based support
Author(s) -
Cal Marta,
Jaremko Mariusz,
Jaremko Łukasz,
Stefanowicz Piotr
Publication year - 2013
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.2466
Subject(s) - ethylene glycol , linker , peptide , peptide synthesis , chemistry , solid phase synthesis , combinatorial chemistry , hydroxamic acid , phase (matter) , organic chemistry , biochemistry , computer science , operating system
A novel resin designed for solid‐phase synthesis of peptide hydroxamic acids (PHA) combining the trityl linker with poly(ethylene glycol)‐based support, ChemMatrix® type, is described. The synthesis of PHA can be performed according to a standard protocol, providing products in excellent purity and reasonable yields. Copyright © 2012 European Peptide Society and John Wiley & Sons, Ltd.