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Stereoselective synthesis of fully protected (2 S ,4 S ,6 S )‐2‐amino‐6‐hydroxy‐4‐methyl‐8‐oxodecanoic acid (AHMOD)
Author(s) -
Zhang Wei,
Li Xiangpeng,
Ding Ning,
Li Yingxia
Publication year - 2012
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.1433
Subject(s) - stereoselectivity , chemistry , alkylation , stereochemistry , derivative (finance) , amino acid , grignard reaction , organic chemistry , catalysis , biochemistry , reagent , financial economics , economics
The stereocontrolled synthesis of fully protected (2 S ,4 S ,6 S )‐2‐amino‐6‐hydroxy‐4‐methyl‐8‐oxodecanoic acid was accomplished using a glutamate derivative as starting material. The key steps of this stereochemical synthetic pathway involved an Evans asymmetric alkylation, a Sharpless asymmetric epoxidation, and a Grignard reaction. Copyright © 2012 European Peptide Society and John Wiley & Sons, Ltd.