Stereoselective synthesis of fully protected (2 S ,4 S ,6 S )‐2‐amino‐6‐hydroxy‐4‐methyl‐8‐oxodecanoic acid (AHMOD) | Zendy

Zhang Wei | Zendy; Li Xiangpeng | Zendy; Ding Ning | Zendy; Li Yingxia | Zendy

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Stereoselective synthesis of fully protected (2 S ,4 S ,6 S )‐2‐amino‐6‐hydroxy‐4‐methyl‐8‐oxodecanoic acid (AHMOD)

Author(s) -

Zhang Wei,

Li Xiangpeng,

Ding Ning,

Li Yingxia

Publication year - 2012

Publication title -

journal of peptide science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 66

eISSN - 1099-1387

pISSN - 1075-2617

DOI - 10.1002/psc.1433

Subject(s) - stereoselectivity , chemistry , alkylation , stereochemistry , derivative (finance) , amino acid , grignard reaction , organic chemistry , catalysis , biochemistry , reagent , financial economics , economics

The stereocontrolled synthesis of fully protected (2 S ,4 S ,6 S )‐2‐amino‐6‐hydroxy‐4‐methyl‐8‐oxodecanoic acid was accomplished using a glutamate derivative as starting material. The key steps of this stereochemical synthetic pathway involved an Evans asymmetric alkylation, a Sharpless asymmetric epoxidation, and a Grignard reaction. Copyright © 2012 European Peptide Society and John Wiley & Sons, Ltd.

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