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Peptide synthesis ‘in water’ by a solution‐phase method using water‐dispersible nanoparticle Boc‐amino acid
Author(s) -
Hojo Keiko,
Ichikawa Hideki,
Onishi Mare,
Fukumori Yoshinobu,
Kawasaki Koichi
Publication year - 2011
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.1367
Subject(s) - yield (engineering) , peptide synthesis , nanoparticle , chemistry , phase (matter) , peptide , amino acid , combinatorial chemistry , organic chemistry , nanotechnology , materials science , biochemistry , metallurgy
Abstract Regulatory pressure has compelled the chemical manufacturing industry to reduce the use of organic solvents in synthetic chemistry, and there is currently a strong focus on replacing these solvents with water. Here, we describe an efficient in‐water solution‐phase peptide synthesis method using Boc‐amino acids. It is based on a coupling reaction utilizing suspended water‐dispersible nanoparticle reactants. Using this method, peptides were obtained in good yield and with high purity. Copyright © 2011 European Peptide Society and John Wiley & Sons, Ltd.