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Peptides from Royal Jelly: studies on the antimicrobial activity of jelleins, jelleins analogs and synergy with temporins
Author(s) -
Romanelli Alessandra,
Moggio Loredana,
Montella Rosa Chiara,
Campiglia Pietro,
Iannaccone Marco,
Capuano Federico,
Pedone Carlo,
Capparelli Rosanna
Publication year - 2011
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.1316
Subject(s) - listeria monocytogenes , antimicrobial peptides , antimicrobial , staphylococcus aureus , bacteria , microbiology and biotechnology , royal jelly , chemistry , antibacterial activity , peptide , biochemistry , biology , food science , genetics
Peptides isolated from natural fonts are the object of several studies aimed at finding new molecules possessing antibacterial activity. We focused our studies on peptides originally isolated from the Royal Jelly, the jelleins and on some analogs having a UV reporter at the N ‐ or C ‐terminus. We found that jelleins are mainly active against gram‐positive bacteria; interestingly, they act in synergy with peptides belonging to the family of temporins such as temporin A and temporin B against Staphylococcus aureus A170 and Listeria monocytogenes . Copyright © 2011 European Peptide Society and John Wiley & Sons, Ltd.