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Peptide–peptoid hybrids based on (1–11)‐parathyroid hormone analogs
Author(s) -
Caporale A.,
Schievano E.,
Peggion E.
Publication year - 2010
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.1265
Subject(s) - peptoid , peptide , chemistry , parathyroid hormone , medicine , biochemistry , calcium
A series of peptide–peptoid hybrids, containing N ‐substituted glycines, were synthesized based on the H‐Aib‐Val‐Aib‐Glu‐Ile‐Gln‐Leu‐Nle‐His‐Gln‐Har‐NH 2 (Har = Homoarginine) as the parent parathyroid hormone (1–11) analog. The compounds were pharmacologically characterized in their agonistic activity at the parathyroid hormone 1 receptor. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.
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