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Evolutionary mechanism as a template for protein engineering
Author(s) -
Eisenbeis Simone,
Höcker Birte
Publication year - 2010
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.1233
Subject(s) - protein engineering , protein evolution , mechanism (biology) , adaptability , function (biology) , computer science , directed evolution , evolutionary algorithm , computational biology , biology , evolutionary biology , artificial intelligence , genetics , biochemistry , physics , gene , ecology , quantum mechanics , mutant , enzyme
The goal of a protein engineer is to adjust a protein to a specified new function. This is exactly what natural evolution has achieved many times. By studying evolutionary mechanisms, we can learn about ways to use the adaptability of proteins and to build new proteins. In fact, many techniques used in engineering are successfully mimicking evolutionary processes. We introduce the fundamental evolutionary mechanisms, take a closer look at duplication and fusion, recombination, and circular permutation and discuss their influence on protein engineering. Some important techniques are presented and illustrated with examples. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.