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‘Sulfo‐click’ for ligation as well as for site‐specific conjugation with peptides, fluorophores, and metal chelators
Author(s) -
Rijkers Dirk T. S.,
Merkx Remco,
Yim ChengBin,
Brouwer Arwin J.,
Liskamp Rob M. J.
Publication year - 2010
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.1197
Subject(s) - click chemistry , chemistry , combinatorial chemistry , thio , azide , chelation , fluorescence , peptide , dendrimer , biochemistry , stereochemistry , organic chemistry , physics , quantum mechanics
The ‘sulfo‐click’ reaction, which is a chemoselective amidation reaction involving the reaction of an aminoethane sulfonyl azide with a thio acid, encompasses a new approach for ligation and conjugation. Detailed protocols are provided for decorating biologically active peptides or dendrimers with biophysical tags, fluorescent probes, metal chelators, and small peptides by using this reaction as a novel, metal‐free ‘sulfo‐click’ approach. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.

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