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Building blocks for the synthesis of post‐translationally modified glycated peptides and proteins
Author(s) -
Carganico Stefano,
Rovero Paolo,
Halperin Jose A.,
Papini Anna Maria,
Chorev Michael
Publication year - 2009
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.1105
Subject(s) - moiety , peptide , chemistry , amadori rearrangement , peptide synthesis , combinatorial chemistry , posttranslational modification , stereochemistry , biochemistry , glycation , receptor , enzyme
Growing interest in synthetic peptides carrying post‐traslational modifications, in general, and the Amadori modification in particular, raises the need for specific building blocks that can be used in stepwise peptide synthesis. Herein, we report the synthesis of N α ‐Fmoc‐Lys‐OH derivatives containing N ε ‐1‐deoxyfructopyranosyl moiety. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.