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Ribosome's mode of function: myths, facts and recent results
Author(s) -
Wekselman Itai,
Davidovich Chen,
Agmon Ilana,
Zimmerman Ella,
Rozenberg Haim,
Bashan Anat,
Berisio Rita,
Yonath Ada
Publication year - 2009
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.1077
Subject(s) - ribosome , mythology , genetic code , flexibility (engineering) , function (biology) , computational biology , biology , computer science , genetics , rna , amino acid , mathematics , gene , literature , art , statistics
Ribosomes translate the genetic code into proteins in all living cells with extremely high efficiency, owing to their inherent flexibility and to their spectacular architecture. During the last 6 decades, extensive effort has been made to elucidate the molecular mechanisms associated with their function, and a quantum jump has been made in recent years, once the three dimensional structures of ribosomes and their functional complexes have been determined. These illuminated key issues in ribosome function, confirmed various biochemical, genetic, and medical findings, and revealed mechanistic details beyond previous expectation, thus leading to conceptual revolutions, and turning old myths into actual facts. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.