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Convenient syntheses of homopropargylglycine
Author(s) -
Dong Shouliang,
Merkel Lars,
Moroder Luis,
Budisa Nediljko
Publication year - 2008
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.1065
Subject(s) - strecker amino acid synthesis , yield (engineering) , chemistry , stereochemistry , peptide , combinatorial chemistry , enantioselective synthesis , organic chemistry , biochemistry , catalysis , materials science , metallurgy
An improved classic Strecker synthesis was elaborated leading to racemic homopropargylglycine (Hpg) in 61% overall yield, while an asymmetric Strecker reaction produced Hpg and the higher homolog 2‐aminohept‐6‐ynoic acid in significantly higher yields and over 80% ee. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
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