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Glycopeptide dendrimers, Part III—a review: Use of glycopeptide dendrimers in immunotherapy and diagnosis of cancer and viral diseases
Author(s) -
Niederhafner Petr,
Reiniš Milan,
Šebestík Jaroslav,
Ježek Jan
Publication year - 2008
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.1011
Subject(s) - glycopeptide , dendrimer , epitope , immunotherapy , chemistry , cancer , cancer immunotherapy , antigen , peptide , computational biology , biochemistry , combinatorial chemistry , immunology , medicine , immune system , biology , antibiotics
Glycopeptide dendrimers containing different types of tumor associated‐carbohydrate antigens (T N , TF, sialyl‐T N , sialyl‐TF, sialyl‐Le x , sialyl‐Le a etc.) were used in diagnosis and therapy of different sorts of cancer. These dendrimeric structures with incorporated T‐cell epitopes and adjuvants can be used as antitumor vaccines. Best results were obtained with multiantigenic vaccines, containing, e.g. five or six different TAAs. The topic of TAAs and their dendrimeric forms at molecular level are reviewed, including structure, syntheses, and biological activities. Use of glycopeptide dendrimers as antiviral vaccines against HIV and influenza is also described. Their syntheses, physico‐chemical properties, and biological activities are given with many examples. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.