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β‐Actin‐derived peptides isolated from acidic extract of rat spleen suppress tumor cell growth
Author(s) -
Blishchenko Elena Y.,
Sazonova Olga V.,
Yatskin Oleg N.,
Kalinina Olga A.,
Tolmazova Anna G.,
Philippova Marina M.,
Karelin Andrei A.,
Ivanov Vadim T.
Publication year - 2008
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/psc.1008
Subject(s) - cytotoxic t cell , actin , peptide , spleen , chemistry , inhibitory postsynaptic potential , microbiology and biotechnology , biochemistry , biology , immunology , in vitro , endocrinology
Twenty‐two fragments of β‐actin and β‐actin‐related protein were isolated from the acidic extracts of rat spleen tissue. β‐Actin fragments (75–90), (78–89), and (78–88), 0.01–1 µ M , decreased live cell number of L929 murine tumor fibroblasts by 80–90%, with maximal cytotoxic effect of 30–40%. The fragments of (78–90) segment and the fragment of β‐actin‐related protein (69–77) were less active (inhibitory effect up to 55%, cytotoxic–up to 25%). Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
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