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Antifungal activity of limonoids from Khaya ivorensis
Author(s) -
Abdelgaleil Samir AM,
Hashinaga Fumio,
Nakatani Munehiro
Publication year - 2005
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.978
Subject(s) - meliaceae , penicillium expansum , botrytis cinerea , mycelium , bark (sound) , biology , antibacterial activity , antifungal , fungus , pathogenic fungus , botany , traditional medicine , microbiology and biotechnology , chemistry , bacteria , medicine , ecology , postharvest , genetics
Chemical investigation of the diethyl ether extract of the stem bark of Khaya ivorensis A Chev (Meliaceae) afforded ten limonoids of angolensates, ring D‐opened limonoids and mexicanolides. The structures of the limonoids isolated were determined by comparison of their 1 H and 13 C NMR data with those reported in the literature. These compounds were evaluated for their antifungal activity against the plant pathogenic fungus Botrytis cinerea Pers. Methyl 6‐hydroxyangolensate and 3,7‐dideacetylkhivorin were also tested for their antifungal and antibacterial activities on several fungal and bacterial species. Methyl angolensate and 1,3,7‐trideacetylkhivorin displayed the highest antifungal activity against B cinerea , with respectively 62.8 and 64.0% mycelial growth inhibition at 1000 mg litre −1 , and 73.3 and 68.6% mycelial growth inhibition at 1500 mg litre −1 . 3,7‐Dideacetylkhivorin showed stronger antifungal and antibacterial activities than methyl 6‐hydroxyangolensate against all of the test fungi and bacteria except Penicillium expansum Link. This is the first report on the antifungal and antibacterial effects of these limonoids. Structure‐antifungal activity relationships of the limonoids isolated are discussed. Copyright © 2004 Society of Chemical Industry