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Synthesis and insecticidal activity of 5‐acyloxyimino‐5‐deoxyavermectin B1 derivatives
Author(s) -
Xiguang Liu,
Jingping Wu,
Xiaomei Liang,
Daoquan Wang
Publication year - 2004
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.859
Subject(s) - exigua , helicoverpa armigera , avermectin , oxime , spodoptera , stereochemistry , chemistry , noctuidae , carbon 13 nmr , mythimna separata , muscidae , proton nmr , organic chemistry , biology , larva , biochemistry , botany , recombinant dna , anatomy , gene
Four novel 5‐acyloxyimino‐5‐deoxyavermectin B1 compounds have been synthesized from avermectin B1 by selective oxidization of the hydroxy group at C‐5, followed by oximation and convenient esterification. Their structures were confirmed by IR, 1 H NMR, 13 C NMR and MS. Insecticidal activities of the intermediate oxime and the four new acyl derivatives were evaluated against Helicoverpa armigera , Spodoptera exigua and Musca domestica . Copyright © 2004 Society of Chemical Industry