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Mode of action and efficacy of quinolinic acid for the control of Ceratocystis fimbriata on sweet potato
Author(s) -
Chen Ying,
Zhou YiDong,
Laborda Pablo,
Wang HaiLin,
Wang Rui,
Chen Xian,
Liu FengQuan,
Yang DongJing,
Wang SuYan,
Shi XinChi,
Laborda Pedro
Publication year - 2021
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.6495
Subject(s) - fungicide , biology , mycelium , ergosterol , ceratocystis , carbendazim , iprodione , mode of action , botany , biochemistry , fungus
BACKGROUND Ceratocystis fimbriata is a hazardous fungal pathogen able to cause black rot disease on sweet potato. The management of C. fimbriata strongly relies on the use of toxic fungicides, and there is a lack of efficient alternative strategies. RESULTS The antifungal properties of quinolinic acid (QA) were studied for the first time, indicating that QA shows selective antifungal activity against C. fimbriata . QA inhibited completely the mycelial growth of C. fimbriata at less than 0.8 mg mL –1 concentration (pH 4), and was able to produce alterations in the fungal cell wall, and to impede spore agglutination and mycelium formation. QA significantly reduced the concentration of ergosterol, and was able to associate to iron (II), suggesting that QA may be a lanosterol 14‐α demethylase inhibitor. In preventive applications, QA reduced the disease incidence of C. fimbriata on sweet potato by 75%, achieving higher control efficacy in comparison with commercial fungicides prochloraz and carbendazim. CONCLUSIONS The first selective antifungal agent against C. fimbriata was discovered in this work, and showed suitable antifungal properties for the management of black rot disease. © 2021 Society of Chemical Industry.