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Unique post‐translational modifications diversify the sodium channels in peach aphid ( Myzus persicae [Sulzer])
Author(s) -
Wang Hao,
Duan WenBo,
Gao Ruibo,
Li Fen,
Yang Lei,
Li WeiZheng,
Yin XinMing,
Wu ShaoYing
Publication year - 2021
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.6489
Subject(s) - myzus persicae , aphid , biology , pest analysis , botany , exon , sodium channel , horticulture , genetics , gene , chemistry , sodium , organic chemistry
BACKGROUND Myzus persicae (Sulzer), a worldwide pest, has caused remarkable damage to agriculture. Among the various control methods, chemical control (especially pyrethroids) is most commonly used. The targets of pyrethroids are voltage‐gated sodium channels (Na v s). Unlike those of other insects, all Na v s of aphids (including two genes), such as Myzus persicae , are unique. RESULTS In this study, three interlock patterns, I(918)‐F(1014), L(918)‐L(1014), and T(918)‐F(1014), were found at sites 918 and 1014 in the sensitive Myzus persicae strain. Similar to that of other aphids, the Na v of Myzus persicae (MpNa v ) consisted of two parts, that is MpNa v ‐I and MpNa v ‐II, which were embedded with an atypical ‘DENS’ ion selectivity filter and a conventional ‘MFM’ inactivation gate, respectively. MpNa v had 11 alternative exons, including two mutually exclusive exons (k and l) and three exons (w, x, and t), which were located in domains I and III, respectively. In addition, various RNA editing events, A503T and V588A, appearing between the connection of domains I and II and the S3 of domain IV, respectively, had been described. CONCLUSION Overall, MpNa v was characterized by unique post‐translational regulation mode, 918 and 1014 interlocks, and unusually alternative exons. Our research provides a new perspective on the evolution and variation of insect Na v s. © 2021 Society of Chemical Industry