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Florylpicoxamid, a new picolinamide fungicide with broad spectrum activity
Author(s) -
Yao Chenglin,
Meyer Kevin G,
Gallup Courtney,
Bowling Andrew J,
Hufnagl Andrea,
Myung Kyung,
Lutz Jamie,
Slanec Thomas,
Pence Heather E,
Delgado Javier,
Wang Nick X
Publication year - 2021
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.6483
Subject(s) - fungicide , basidiomycota , biology , strobilurin , spore germination , mycelium , broad spectrum , tebuconazole , ascomycota , horticulture , botany , azoxystrobin , germination , biochemistry , chemistry , combinatorial chemistry , gene
BACKGROUND Following the introduction of fenpicoxamid, a natural product‐based fungicide targeting the Qi site of mitochondrial cytochrome bc1 complex, a second generation fully synthetic picolinamide, florylpicoxamid, was discovered and its biological activity and attributes were characterized. RESULTS In vitro fungal growth inhibition assays and in planta glasshouse biological activity evaluations showed florylpicoxamid was active against 21 different plant pathogenic fungi within the phyla Ascomycota and Basidiomycota. Among the pathogens evaluated, florylpicoxamid was most potent against Zymoseptoria tritici , the causal organism of wheat leaf blotch, providing 80% growth inhibition in vitro at 0.0046 mg L −1 and 80% disease control in planta at 0.03 mg L −1 when applied as a preventative treatment. Florylpicoxamid was more efficacious than epoxiconazole, fluxapyroxad, and benzovindiflupyr versus a Z. tritici wild‐type isolate when applied as curative and preventative treatments, with superior 10‐day curative reachback activity. Analytical studies and in planta tests demonstrated that florylpicoxamid partitioned into plants quickly and showed good systemicity and translaminar activity on both monocot and dicot plants. No cross‐resistance was observed between florylpicoxamid and strobilurin or azole fungicides. Florylpicoxamid exerts its preventative effect by preventing spore germination on the leaf surface and curative activity by arresting mycelial growth and pycnidia development in leaf tissue. CONCLUSIONS With strong broad spectrum fungicidal activity, florylpicoxamid delivers an innovative solution for growers to sustain high productivity and quality of many crops, and also provides a new option for developing effective strategies for fungicide resistance management. © 2021 Society of Chemical Industry.