Premium
Synthesis and insecticidal activity of benzoheterocyclic analogues of N ′‐benzoyl‐ N ‐( tert ‐butyl)benzohydrazide: Part 3. Modification of N‐tert ‐butylhydrazine moiety
Author(s) -
Sawada Yoshihiro,
Yanai Toshiaki,
Nakagawa Harumi,
Tsukamoto Yoshihisa,
Tamagawa Yasushi,
Yokoi Shinji,
Yanagi Mikio,
Toya Tetsuya,
Sugizaki Hiroyasu,
Kato Yasuhito,
Shirakura Hidetoshi,
Watanabe Tetsuo,
Yajima Yoshimi,
Kodama Seiichirou,
Masui Akio
Publication year - 2003
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.606
Subject(s) - moiety , spodoptera litura , carbohydrazide , chemistry , stereochemistry , selectivity , spodoptera , medicinal chemistry , organic chemistry , biology , larva , biochemistry , botany , gene , recombinant dna , catalysis
Nineteen analogues were synthesized by modifying the tert ‐butylhydrazine moieties of N′‐tert ‐butyl‐ N′ ‐(3,5‐dimethylbenzoyl)‐5‐methyl‐2,3‐dihydro‐1,4‐benzodioxine‐6‐carbohydrazide and N′ ‐ tert ‐butyl‐ N′ ‐(3,5‐dimethylbenzoyl)‐5‐methylchromane‐6‐carbohydrazide (chromafenozide), and the synthesized analogues were evaluated for their insecticidal activity against Spodoptera litura F. While all of the synthesized analogues had insecticidal activity inferior to those of the lead compounds, several of the analogues nonetheless showed high insecticidal activity. Chromafenozide has shown very high selectivity toward lepidopteran species. © 2002 Society of Chemical Industry