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Synthesis and insecticidal activity of benzoheterocyclic analogues of N ′‐benzoyl‐ N ‐( tert ‐butyl)benzohydrazide: Part 2. Introduction of substituents on the benzene rings of the benzoheterocycle moiety
Author(s) -
Sawada Yoshihiro,
Yanai Toshiaki,
Nakagawa Harumi,
Tsukamoto Yoshihisa,
Yokoi Shinji,
Yanagi Mikio,
Toya Tetsuya,
Sugizaki Hiroyasu,
Kato Yasuhito,
Shirakura Hidetoshi,
Watanabe Tetsuo,
Yajima Yoshimi,
Kodama Seiichirou,
Masui Akio
Publication year - 2003
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.605
Subject(s) - moiety , benzene , chemistry , stereochemistry , medicinal chemistry , biological activity , organic chemistry , in vitro , biochemistry
A series of N′ ‐benzoheterocyclecarbonyl‐ N ‐ tert ‐butyl‐3,5‐dimethylbenzohydrazide analogues possessing a variety of substituents on the benzene rings of the benzoheterocyle moieties were synthesized and tested for their insecticidal activity. The introduction of a methyl group at the R 1 position of the benzoheterocycle moiety strongly increased the insecticidal activity. Among the analogues synthesized, N′ ‐ tert ‐butyl‐ N′ ‐(3,5‐dimethylbenzoyl)‐5‐methyl‐6‐chromanecarbohydrazide showed the highest insecticidal activity (LC 50 = 0.89 mg litre −1 ). © 2002 Society of Chemical Industry