Premium
Synthesis and insecticidal evaluation of novel N ‐( S ‐amino)sulfenylated derivatives of diacylhydrazines
Author(s) -
Wang Qingmin,
Cheng Junran,
Huang Runqin
Publication year - 2002
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.597
Subject(s) - sodium hydride , bioassay , moulting , cleavage (geology) , toxicity , chemistry , amino acid , larva , biology , medicinal chemistry , stereochemistry , toxicology , biochemistry , organic chemistry , botany , paleontology , genetics , fracture (geology)
A series of new N ‐( S ‐amino)sulfenylated derivatives of diacylhydrazines were synthesized by the reaction of S ‐aminosulfenyl chlorides with N ‐ tert ‐butyl‐ N ′‐benzoyl‐ N ‐substituted benzoylhydrazines in the presence of sodium hydride, and evaluated for moulting hormone mimicking activity. In the course of syntheses, NN bond cleavage in diacylhydrazines was found and the reaction was studied in some detail. The results of bioassay showed that the title compounds exhibit excellent larvicidal activity. Toxicity assays indicated that these compounds can induce a premature, abnormal and lethal larval mount. © 2002 Society of Chemical Industry