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Two novel alkaloids from Corydalis curviflora Maxim. and their insecticidal activity
Author(s) -
Xia JianKai,
Liu Yao,
Zhou Yu,
Zhang JiaYao,
Li ChunHuan,
Yin Xia,
Tian XiangRong,
Zhang XiuYun
Publication year - 2020
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.5772
Subject(s) - mythimna separata , bioassay , biology , traditional medicine , larvicide , pesticide , botany , toxicology , larva , aedes aegypti , agronomy , medicine , genetics
BACKGROUND Botanical pesticide plays an essential role in the control of agricultural pests. Corydalis curviflora Maxim. is used as a cholagogue and larvicide in the rural areas of Northwest China. In this study, our objective was to identify the insect active ingredients of C. curviflora extract. RESULTS Bioassay‐guided isolation of the high active fraction led to the identification of two novel N‐demethyl hexahydrobenzophenanthridine‐type alkaloids, Curviflorain A (1) and Curviflorain B (2), together with nine known alkaloids, ambiguanine A (3), ambiguanine B (4), ambiguanine C (5), 6‐acetylambinine (6), 1,1‐dimethyl‐6‐methoxy‐7‐hydroxyl‐1,2,3,4‐tetrahydroisoquinoline (7), hendersine B (8), coryximine (9), isochotensine (10) and corysolidine (11). Compounds 1, 2, and 6 showed promising activity to the larvae of Culex pipiens pallens Coq. and Aedes albopictus Skuse . These compounds were also tested against the insect pests, Mythimna separata walker. and Schizaphis graminum Rondani. CONCLUSION These findings provide a better understanding of the insecticidal activity of C. curviflora extract and the active compounds. This has the potential to lead to a more effective botanical insecticide.