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Compounds from the root of Pueraria peduncularis (Grah. ex Benth.) Benth. and their antimicrobial effects
Author(s) -
Chen Huabao,
Zhao Xiaomin,
Lv Tianxing,
Qiu Xiaoyan,
Luo Liya,
Zhang Min,
Yang Hui,
Chang Xiaoli,
Li Peili,
Wu ChuanLei,
Xie Deshan,
Qian Yong,
Yang Chunping
Publication year - 2019
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.5387
Subject(s) - antimicrobial , fungicide , biology , botany , rhizoctonia solani , traditional medicine , microbiology and biotechnology , medicine
BACKGROUND Pueraria peduncularis belongs to the genus Pueraria DC , and has a wide range of medical and agricultural activities. Previous studies have shown that P. peduncularis extracts have broad bioactivities against phytopathogens. In this paper, we systematically studied the fungicidal activity of root methanol extracts and further isolated the active compounds. RESULTS The root methanol extract inhibited the mycelial growth of the five tested phytopathogens to different degrees. Among these phytopathogens, the inhibitory effect was greatest against R. solani , with an EC 50 value of 324.72 mg L −1 . Eight compounds were subsequently isolated and identified from P. peduncularis . Among them, puercarpan A and medicarpin showed strong fungicidal activity, with MIC values against Rhizoctonia solani of 1.6 and 6.25 mg L −1 , respectively. Puercarpan A is a new compound, and its structure was established as (6aR,6bS,11aR)‐6b‐hydroxy‐3‐methoxypterocarpan‐10‐ene‐7‐one. CONCLUSION The P. peduncularis extracts exhibit high antimicrobial activity against R. solani and have great potential value of P. peduncularis as a fungicide. © 2019 Society of Chemical Industry