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Structural effects of dinotefuran and analogues in insecticidal and neural activities
Author(s) -
Kiriyama Kazuhisa,
Nishimura Keiichiro
Publication year - 2002
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.493
Subject(s) - clothianidin , periplaneta , imidacloprid , excitatory postsynaptic potential , potency , cockroach , pharmacology , neonicotinoid , biology , chemistry , toxicology , inhibitory postsynaptic potential , endocrinology , pesticide , thiamethoxam , biochemistry , in vitro , ecology
The insecticidal potencies of dinotefuran and analogues against the adult male American cockroach, Periplaneta americana (L) were measured by injection with or without metabolic inhibitors. The potency of dinotefuran was close to those of clothianidin and imidacloprid under the conditions used. The nerve‐excitatory and nerve‐blocking activities were measured with central nerve cords of P americana . The nerve‐excitatory activity of dinotefuran was lower than that of imidacloprid, but was comparable with that of clothianidin. The nerve‐blocking activity of dinotefuran was comparable with that of imidacloprid and slightly higher than that of clothianidin. Quantitative analyses showed that variations in the insecticidal activity were better correlated with variations in the nerve‐blocking activity than with those in the nerve‐excitatory activity when the contribution of the hydrophobic factor was allowed for. © 2002 Society of Chemical Industry