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Antiphytoviral toxins of Actinidia chinensis root bark (ACRB) extract: laboratory and semi‐field trials
Author(s) -
Zhang XiuYun,
Zhou Yu,
Wei ZhiPing,
Shen Jing,
Wang LongKun,
Ma ZhiQing,
Zhang Xing
Publication year - 2018
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.4854
Subject(s) - actinidia chinensis , oleanolic acid , bark (sound) , active ingredient , traditional medicine , biology , betulinic acid , antimicrobial , coumarin , chemistry , botany , pharmacology , microbiology and biotechnology , medicine , ecology , alternative medicine , genetics , pathology
BACKGROUND Actinidia chinensis Planch, which is distributed only in China, has been used to treat hepatitis and cancer. The objective of the present work was to identify the antiviral active ingredient of A. chinensis root bark (ACRB). RESULTS Bioassay‐guided isolation of the most active fraction, the EtOAc extract, led to the identification of seven compounds, (+)‐catechins‐7‐phytol ( 1 ), 5‐methoxy‐coumarin‐7‐ β ‐D‐glycosidase ( 2 ), (+)‐catechins ( 3 ), fupenzic acid ( 4 ), spathodic acid‐28‐O‐ β ‐D‐glucopyranoside ( 5 ), 3‐oxo‐9, 12‐diene‐30‐oic acid ( 6 ), and 3‐ β ‐(2‐carboxy benzoyloxy) oleanolic acid ( 7 ). Of these, 5‐methoxy‐coumarin‐7‐ β ‐D‐glycosidase ( 2 ) possessed the highest antiviral activity, followed by spathodic acid‐28‐O‐ β ‐D‐glucopyranoside ( 5 ). Thus, compounds 2 and 5 were the main active constituents, with potential for further development as biological antiviral agents. CONCLUSION The results suggest that ACRB possesses great potential value for development of an antiviral agent to control phytoviral diseases. © 2018 Society of Chemical Industry

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