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Mesoionic insecticides: a novel class of insecticides that modulate nicotinic acetylcholine receptors
Author(s) -
Holyoke Caleb W,
Cordova Daniel,
Zhang Wenming,
Barry James D,
Leighty Robert M,
Dietrich Robert F,
Rauh James J,
Pahutski Thomas F,
Lahm George P,
Tong MyHanh Thi,
Benner Eric A,
Andreassi John L,
Smith Rejane M,
Vincent Daniel R,
Christianson Laurie A,
Teixeira Luis A,
Singh Vineet,
Hughes Kenneth A
Publication year - 2017
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.4496
Subject(s) - mesoionic , mode of action , nicotinic agonist , biology , toxicology , pharmacology , microbiology and biotechnology , population , insecticide resistance , receptor , chemistry , biochemistry , medicine , environmental health , medicinal chemistry
BACKGROUND As the world population grows towards 9 billion by 2050, it is projected that food production will need to increase by 60%. A critical part of this growth includes the safe and effective use of insecticides to reduce the estimated 20–49% loss of global crop yields owing to pests. The development of new insecticides will help to sustain this protection and overcome insecticide resistance. RESULTS A novel class of mesoionic compounds has been discovered, with exceptional insecticidal activity on a range of Hemiptera and Lepidoptera. These compounds bind to the orthosteric site of the nicotinic acetylcholine receptor and result in a highly potent inhibitory action at the receptor with minimal agonism. The synthesis, biological activity, optimization and mode of action will be discussed. CONCLUSION Triflumezopyrim insect control will provide a powerful tool for control of hopper species in rice throughout Asia. Dicloromezotiaz can provide a useful control tool for lepidopteran pests, with an underexploited mode of action among these pests. © 2016 Society of Chemical Industry