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Quantification of plasma and egg 4,4′‐dinitrocarbanilide (DNC) residues for the efficient development of a nicarbazin‐based contraceptive for pest waterfowl
Author(s) -
Johnston John J,
Britton Walter M,
MacDonald Alexander,
Primus Thomas M,
Goodal Margaret J,
Yoder Christi A,
Miller Lowell A,
Fagerstone Kathleen A
Publication year - 2002
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.439
Subject(s) - waterfowl , branta , biology , pest analysis , zoology , ecology , habitat , goose , botany
Urbanization and associated landscaping has increased the abundance of year‐round habitat for waterfowl, resulting in vegetation damage, loss of recreational activities, air transportation mishaps and health hazards. As part of a research program to develop socially acceptable techniques for management of pest bird populations, we are evaluating nicarbazin as a contraceptive in pest and surrogate avian species. As reproductive studies with Canada Geese ( Branta canadensis ) are tedious due to the difficulty of conducting controlled field studies and/or breeding geese in captivity, we evaluated the effects of oral nicarbazin administration on the production and hatchability of chicken eggs. Blood plasma and egg DNC concentrations were correlated to contraceptive efficacy. Subsequent studies are being conducted with geese to determine the diet nicarbazin concentration required to produce the desired blood and plasma DNC concentrations. This approach permits the expeditious evaluation of formulations and dosing regimes by simply monitoring blood DNC concentrations in target species. Published in 2001 by John Wiley & Sons, Ltd.