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Delivery strategies: RNA interference in agriculture and human health
Author(s) -
Heidebrecht Richard W
Publication year - 2017
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.4341
Subject(s) - rna interference , agrochemical , gene , gene expression , rna , messenger rna , microbiology and biotechnology , agriculture , endogeny , host (biology) , biology , computational biology , biochemistry , genetics , ecology
Crop protection through expression of introduced insecticidal proteins is a well‐established technique. Modifications of endogenous gene expression have also been used successfully to produce safe and effective agrochemical products. The existing gene expression regulatory apparatus can be employed to alter messenger ribonucleic acid ( mRNA ) stability in the host species through a ribonucleic acid interference ( RNAi ) mechanism. Such solutions are currently delivered by incorporation of new genes into the host plant. Direct delivery of RNAi is being extensively explored in the clinic to treat selected human diseases and could be advantageous in agriculture. What are the unifying characteristics of successful delivery agents, and how can we project those observations into the future? © 2016 Society of Chemical Industry