Premium
Dermal pharmacokinetics of the insecticide furathiocarb in rats
Author(s) -
Liu KwangHyeon,
Sung HaJung,
Lee HaeKeun,
Song ByungHun,
Ihm YangBin,
Kim Kyun,
Lee HyeSuk,
Kim JeongHan
Publication year - 2002
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.422
Subject(s) - carbofuran , metabolite , pharmacokinetics , cmax , urine , chemistry , chromatography , high performance liquid chromatography , derivatization , pharmacology , plasma concentration , active metabolite , pesticide , biology , biochemistry , agronomy
The pharmacokinetics of furathiocarb were studied in vivo in male Sprague–Dawley rats following dermal treatment. HPLC and post‐column derivatization were used for the analysis of furathiocarb and its metabolites (carbofuran, 3‐hydroxycarbofuran and 3‐ketocarbofuran). Carbofuran and 3‐hydroxycarbofuran were detected in plasma and urine rather than furathiocarb. 3‐Ketocarbofuran, another potential metabolite, was not observed in any sample. The concentration of carbofuran was higher than that of 3‐hydroxycarbofuran in plasma, but the reverse was the case in urine. The corresponding area under the plasma concentration–time curve, T max , and C max values of carbofuran and 3‐hydroxycarbofuran for 1500 mg kg −1 doses were 2.4–8.0 mg equiv h ml −1 , 12 h and 0.1–0.4 mg equiv ml −1 , respectively. T 1/2 was calculated only for 3‐hydroxycarbofuran (28 h). Two metabolites were excreted in a dose‐dependent manner without saturation. © 2001 Society of Chemical Industry