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In vivo pharmacokinetics of pyribenzoxim in rats
Author(s) -
Liu KwangHyeon,
Moon JoonKwan,
Sung HaJung,
Kang SeungHun,
Koo SukJin,
Lee HyeSuk,
Kim JeongHan
Publication year - 2001
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.409
Subject(s) - pharmacokinetics , cmax , in vivo , feces , oral administration , chemistry , pharmacology , biology , microbiology and biotechnology
Pyribenzoxim, benzophenone O ‐[2,6‐bis(4,6‐dimethoxypyrimidin‐2‐yloxy)benzoyl]oxime, is a new post‐emergence herbicide providing broad‐spectrum weed control in rice fields. [ 14 C]Pyribenzoxim was used to study the pharmacokinetics of the compound after oral administration of a dose of 1000 mg kg −1 to male Sprague–Dawley rats. The material balance ranged from 97.3 to 99.7% of the administered dose and urinary and fecal recovery accounted for 97.1%, with the majority of radioactivity recovered in feces (88.6%) by 168 h after treatment. Elimination as volatile products or as carbon dioxide was negligible. The following values were obtained for the compound in the blood: AUC 0–168h , 28400 µg equiv h g −1 ; T max , 12 h; C max , 372 µg equiv g −1 ; half‐life, 53 h. Radioactivity in tissue decreased from 96.1% of applied radiocarbon at 6 h to 0.4% at 168 h and the highest concentration of radioactivity among the tissues was observed in liver while the lowest residues were found in brain. The elimination half‐lives of radioactivity from tissues was in the range of 7 to 77 h and T max values of 12, 24 and 12 h were observed for blood, liver and kidney, respectively. Except for that in the digestive tract, the tissue‐to‐blood ratio (TBR) was highest in the liver. © 2001 Society of Chemical Industry