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Larvicidal spirobisnaphthalenes from the endophytic fungus Berkleasmium sp. against Aedes albopictus
Author(s) -
Tian Jin,
Liu Xin Chao,
Liu Zhi Long,
Lai Daowan,
Zhou Ligang
Publication year - 2016
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.4075
Subject(s) - aedes albopictus , biology , bioassay , botany , traditional medicine , ethyl acetate , plant use of endophytic fungi in defense , larva , instar , aedes aegypti , ecology , medicine , biochemistry
BACKGROUND In our screening programme for new agrochemicals from endophytic fungi, the ethyl acetate extract of an endophytic Berkleasmium sp. isolated from the medicinal plant Dioscorea zingiberensis was found to possess strong larvicidal activity against the Asian tiger mosquito, Aedes albopictus . RESULTS Bioassay‐guided fractionation of the fungal extract has led to the isolation of seven spirobisnaphthalenes, including palmarumycins C 8 , C 12 , C 15 and B 6 and diepoxins γ, δ and ζ. Among them, palmarumycins C 8 and B 6 showed strong larvicidal activity against the fourth‐instar larvae of A. albopictus , with LC 50 values of 8.83 and 11.51 µg mL −1 respectively. Interestingly, only spirobisnaphthalenes with a chlorine substituent possessed strong larvicidal activity. CONCLUSION The results indicated that the spirobisnaphthalenes derived from the endophytic fungus Berkleasmium sp. could be promising leads for the development of new larvicides against A. albopictus . © 2015 Society of Chemical Industry