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Ryanodine receptor acts as a sensor for redox stress
Author(s) -
Pessah Isaac N
Publication year - 2001
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.391
Subject(s) - ryanodine receptor , context (archaeology) , xenobiotic , redox , chemistry , transmembrane protein , biochemistry , effector , receptor , biophysics , microbiology and biotechnology , biology , enzyme , paleontology , organic chemistry
Ryanoids have not attained importance as insecticides, but the increasing number of xenobiotic effectors known to influence Ca 2+ signalling by interaction with ryanodine receptors (RyRs) may serve to identify new targets for insect control. A historical review of redox control of microsomal Ca 2+ transport is given here, followed by recent evidence indicating that hyperactive Cys residues are an essential component of a transmembrane redox sensor. Focus is on the role of sulfhydryl chemistry in RyR regulation; metabolic quinonoid intermediates from pesticides and other environmental contaminants are of interest in this context. © 2001 Society of Chemical Industry