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Differential mechanisms of action of the novel γ ‐aminobutyric acid receptor antagonist ectoparasiticides fluralaner ( A1443 ) and fipronil
Author(s) -
Asahi Miho,
Kobayashi Masaki,
Matsui Hiroto,
Nakahira Kunimitsu
Publication year - 2015
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.3768
Subject(s) - fipronil , acaricide , biology , pharmacology , toxicology , pesticide , agronomy
BACKGROUND Fluralaner ( A1443 ) is an isoxazoline ectoparasiticide that is a novel antagonist of γ ‐aminobutyric acid ( GABA ) receptors ( GABARs ), with a potency comparable to that of fipronil, a phenylpyrazole ectoparasiticide. To clarify the biological effectiveness of fluralaner against fipronil‐resistant pests, differences in the actions of fluralaner and fipronil on GABARs that possess resistance to dieldrin ( rdl )‐type mutations were evaluated. RESULTS Fipronil had neither pest control nor GABAR ‐antagonistic activities against two‐spotted spider mites ( Tetranychus urticae ) that had two different rdl ‐type amino acids ( A 301 → H and T 350 → A: Drosophila melanogaster GABAR numbering) and against small brown planthoppers ( Laodelphax striatellus ) that had a novel rdl ‐type ( A 283 → N) mutation in GABARs . In contrast, fluralaner showed not only high pest control activities against these pests, but also excellent antagonistic activities for these rdl ‐type GABARs . CONCLUSION The findings indicate that rdl ‐type fipronil‐resistant pests do not show cross‐resistance to fluralaner owing to the differential actions of fluralaner and fipronil on the GABAR . © 2014 Society of Chemical Industry