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Cyflumetofen, a novel acaricide – its mode of action and selectivity
Author(s) -
Hayashi Naotaka,
Sasama Yasuhiro,
Takahashi Nobuyoshi,
Ikemi Naoki
Publication year - 2013
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.3470
Subject(s) - acaricide , mode of action , metabolite , biology , selectivity , spider , mitochondrion , chemistry , toxicology , stereochemistry , zoology , biochemistry , catalysis
Background Cyflumetofen is a novel acaricide developed by Otsuka AgriTechno Co., Ltd. It affects only spider mites and has no effect on insects, crustaceans or vertebrates under conditions of practical use. The mode of action of cyflumetofen, its selectivity for mites and its safety for insects and vertebrates were investigated . Results The research showed that cyflumetofen inhibited mitochondria complex II in mites. In addition, the de‐esterified form ( AB ‐1) of cyflumetofen inhibited mitochondria complex II at extremely low concentrations. AB ‐1 was also detected as the main metabolite in mites . Conclusion The mode of action of cyflumetofen is to inhibit mitochondria complex II by affecting its action site after being metabolised to AB ‐1. However, inhibition by cyflumetofen and AB ‐1 in other organisms was very weak. Selectivity for other organisms has contributed to differences in action site activities. © 2012 Society of Chemical Industry