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Insecticidal activity against Aedes aegypti of m ‐pentadecadienyl‐phenol isolated from Myracrodruon urundeuva seeds
Author(s) -
Souza Terezinha M,
Cunha Arcelina P,
Farias Davi F,
Machado Lyeghyna K,
Morais Selene M,
Ricardo Nágila MPS,
Carvalho Ana FU
Publication year - 2012
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.3316
Subject(s) - aedes aegypti , larva , biology , traditional medicine , dengue fever , veterinary medicine , botany , virology , medicine
BACKGROUND: Myracrodruon urundeuva Fr. Allemao is a common tree in the Caatinga that has been widely used for various medical purposes. Previous studies showed that the ethanol seed extract of M. urundeuva has potent activity against the larval stage of the dengue vector Aedes aegypti. Given this potential insecticidal activity, bioguided separation steps were performed in order to isolate the active compound(s). RESULTS: The isolation process resulted in only one active chemical compound, identified by infrared spectroscopy and mass spectrometry as m ‐pentadecadienyl‐phenol. This compound presented potent larvicidal and pupicidal activity (LC 50 10.16 and 99.06 µg mL −1 respectively) and great egg hatching inhibitory activity (IC 50 49.79 µg mL −1 ). The mode of action was investigated through observations of behavioural and morphological changes performed in third‐instar larvae treated with m ‐pentadecadienyl‐phenol solution after 1, 6, 12, 16 and 20 h of exposure. Some changes were observed as flooding of the tracheal system, alterations in siphonal valves and anal gills and lethargy, probably caused by the strong anticholinesterasic activity reported previously. CONCLUSION: The compound isolated from M. urundeuva seeds, m ‐pentadecadienyl‐phenol, showed potent activity against immature stages of dengue vector, Ae. aegypti, being considered the main larvicidal principle. Copyright © 2012 Society of Chemical Industry