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In vitro antimicrobial and in vivo antioomycete activities of the novel antibiotic thiobutacin
Author(s) -
Lee Jung Yeop,
Sherman David H,
Hwang Byung Kook
Publication year - 2008
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.1494
Subject(s) - oomycete , phytophthora capsici , zoospore , fungicide , biology , phytophthora , microbiology and biotechnology , in vivo , downy mildew , antimicrobial , botany , pathogen , spore
Abstract BACKGROUND: A number of synthetic fungicides are not effective when confronted by oomycete pathogens because many fungicide targets are absent from oomycetes. Moreover, resistance to fungicides has already arisen in oomycete species, and thus development of new, effective and safe compounds for use in oomycete disease control is necessary. RESULTS: Zoospore lysis began at 10 µg mL −1 of thiobutacin, and most of the zoospores were collapsed at 50 µg mL −1 . Thiobutacin also revealed inhibitory activity against the cyst germination and hyphal growth of Phytophthora capsici at 50 µg mL −1 . Treatment with thiobutacin exhibited protective activity against development of Phytophthora disease on pepper plants. CONCLUSION: The authors verified in vitro antioomycete activity of thiobutacin against P. capsici and its control efficacy against Phytophthora blight in vivo . This is the first report to demonstrate in vivo antioomycete activity of the novel antibiotic thiobutacin against P. capsici infection. Copyright © 2007 Society of Chemical Industry