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Use of pyrethroid analogues to identify key structural features for enhanced esterase resistance in Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae)
Author(s) -
Gunning Robin V,
Moores Graham D,
Jewess Philip,
Boyes Alastair L,
Devonshire Alan L,
Khambay Bhupinder PS
Publication year - 2007
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.1377
Subject(s) - helicoverpa armigera , esterase , noctuidae , pyrethroid , lepidoptera genitalia , biology , bioassay , pesticide resistance , biochemistry , microbiology and biotechnology , toxicology , enzyme , botany , pesticide , genetics , agronomy
It has been reported previously that the major resistance mechanism to pyrethroid insecticides by the cotton bollworm Helicoverpa armigera (Hübner) in Australia is a consequence of overproduction of esterase isoenzymes. This paper reports structure–activity relationships that support such a view, based on in vivo bioassays conducted with a range of pyrethroid structures containing a variety of acid and alcohol moieties and the correlation with in vitro esterase inhibition assays against the same structures, and identifies the critical regions of the molecule with regard to esterase inhibition, and hence resistance. The implications of this work in terms of possible resistance management are evaluated and discussed. Copyright © 2007 Society of Chemical Industry