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Effect of substituents at the 5‐position of the pyridine ring of imidacloprid on insecticidal activity against Periplaneta americana
Author(s) -
Kagabu Shinzo,
Murase Yuko,
Imai Rie,
Ito Nakako,
Nishimura Keiichiro
Publication year - 2007
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.1326
Subject(s) - periplaneta , piperonyl butoxide , chemistry , imidacloprid , ring (chemistry) , pyridine , chlorine , stereochemistry , american cockroach , cockroach , derivative (finance) , medicinal chemistry , toxicology , organic chemistry , toxicity , pesticide , biology , ecology , financial economics , agronomy , economics
The insecticidal activities of imidacloprid derivatives with a wide range of substituents at the 5‐position on the pyridine ring against American cockroaches, Periplaneta americana (L.), were measured by injection with and without synergists propyl 2‐propynyl phenylphosphonate and piperonyl butoxide. The log(1/MLD) value (MLD = minimal lethal dose in mol) without synergists was 7.96 for the methyl derivative, and the values were lower for other derivatives. Synergists enhanced the potencies of all the compounds tested. Considering these compounds and those with other substituents at this position, the region for maximum activity was predicted to be in the conjunction of the pyridyl 6‐chlorine atom with a lipophilic small group in the 5‐position. Copyright © 2007 Society of Chemical Industry