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Masking the taste of the conditioned taste aversion agent levamisole using an ion‐exchange resin, for practical application in wildlife management
Author(s) -
Cotterill Jane V,
Massei Giovanna,
Cowan David P
Publication year - 2006
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.1129
Subject(s) - levamisole , amberlite , taste , taste aversion , ion exchange resin , chemistry , food science , chromatography , medicine , organic chemistry , adsorption
For a conditioned taste aversion (CTA) agent to be successful in wildlife management applications, the compound must not be detectable by the animal. Levamisole is an effective CTA agent when administered by oral intubation, but it is readily detected by a number of species when mixed directly in food. This paper describes the development of an ion‐exchange resin complex (resinate) to mask the taste of levamisole. Two different resins were evaluated, Amberlite ® IRP‐64 and Amberlite ® IRP‐69, and release studies indicated that the resinate formed using IRP‐64 resin would be most suitable for use in wildlife management. Although it contained a relatively low loading of levamisole (77 g kg −1 ), the results indicated that the IRP‐64 resinate should be stable in the mouth and release the levamisole quickly in the acid environment of the stomach (93% of levamisole was released into 0.1 M HCl in 5 min). In a bioassay using laboratory rats ( Rattus norvegicus Berk), we showed that the taste of levamisole was successfully masked in a biscuit bait using the IRP‐64 resinate and that a CTA was generated to untreated bait. The use of ion‐exchange resins is a new approach in the taste‐masking of CTA agents and could be applied to other wildlife management applications. © British Crown copyright 2005. Reproduced with the permission of Her Majesty's Stationery Office. Published for SCI by John Wiley & Sons, Ltd.