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Insecticidal activity of the pyrimidine nucleoside analogue ( E )‐5‐(2‐bromovinyl)‐2′‐deoxyuridine (BVDU)
Author(s) -
Breuer Michael,
De Loof Arnold,
Balzarini Jan,
Huybrechts Roger
Publication year - 2005
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.1053
Subject(s) - noctuidae , deoxyuridine , biology , spodoptera , in vivo , hatching , lepidoptera genitalia , larva , nucleoside , nucleoside analogue , thymidine , lymantria dispar , pyrimidine , biochemistry , in vitro , botany , zoology , genetics , dna , gene , recombinant dna
The insecticidal activity of the antiherpetic agent ( E )‐5‐(2‐bromovinyl)‐2′‐deoxyuridine (BVDU) was assessed in in vivo assays against the fall armyworm, Spodoptera frugiperda (JE Smith) (Lepidoptera, Noctuidae). BVDU, mixed into an artificial diet, caused a variety of effects, depending on the concentration used. Compared with controls, food intake was lower, larval growth was retarded and larval development was prolonged. The treated larvae formed smaller pupae and the hatching moths often showed morphogenetic defects. A higher mortality could be found in larval and pupal stages and was generally caused by moult disruption. A choice assay showed that BVDU has very slight feeding‐deterrent properties, which only partly explain the toxic effects. The agent most probably acts through its cytostatic activity that has been described previously using cell lines of different insect species. Copyright © 2005 Society of Chemical Industry