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Isolation and antifungal activity of kakuol, a propiophenone derivative from Asarum sieboldii rhizome
Author(s) -
Lee Jung Yeop,
Moon Surk Sik,
Hwang Byung Kook
Publication year - 2005
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.1050
Subject(s) - botrytis cinerea , rhizome , biology , mycelium , fungicide , chlorothalonil , botany , microbiology and biotechnology
An antifungal substance active against Colletotrichum orbiculare (Berk & Mont) Arx was isolated from the methanol extracts of Asarum sieboldii (Miq) Maek rhizomes. High‐resolution MS, NMR and UV spectral data confirmed that the antifungal substance is kakuol, 2‐hydroxy‐4,5‐methylenedioxypropiophenone. Colletotrichum orbiculare was most sensitive to kakuol, with MIC of 10 µg ml −1 . Kakuol also completely inhibited the mycelial growth of Botrytis cinerea Pers ex Fr and Cladosporium cucumerinum Ellis & Arthur at 50 µg ml −1 and 30 µg ml −1 , respectively. However, no antimicrobial activity was found against yeast and bacteria even at 100 µg ml −1 . Kakuol exhibited a protective activity against the development of anthracnose disease on cucumber plants. The control efficacy of kakuol against the anthracnose disease was in general somewhat less than that of the commercial fungicide chlorothalonil. This is the first report to demonstrate in vitro and in vivo antifungal activity of kakuol against C orbiculare infection. Copyright © 2005 Society of Chemical Industry