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Stability of the tranquilizer drug propionylpromazine hydrochloride in formulated products
Author(s) -
Primus Thomas M,
Kimball Bruce A,
Hurley Jerome,
Johnston John J,
Blom Sherm,
Savarie Peter J
Publication year - 2005
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/ps.1018
Subject(s) - tranquilizer , hydrochloride , chemistry , biology , pharmacology , organic chemistry
An analytical method to evaluate propionylpromazine hydrochloride (PPZHCl) in tranquilizer formulations was developed using high‐performance liquid chromatography (HPLC). During analysis of aged quality‐control samples, a previously unreported chromatographic response was observed at a shorter retention time than PPZHCl. Further investigation of formulations stored in trap tap devices at temperatures ranging from 5 to 40 °C during field trials at four different locations confirmed the degradation of the active ingredient. Further investigation using HPLC/tandem mass spectrometry revealed two to five degradates, with the major degradates being oxidation products of the active ingredient, PPZHCl. As PPZHCl formulations must be stable when stored at 5 to 40 °C for 6 to 12 months, reformulation with the anti‐oxidant ascorbic acid was utilized to achieve the required PPZHCl stability. Copyright © 2005 Society of Chemical Industry